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`!Piezo-type mechanosensitive ion channel component 2`! is a `F33f`_`[protein`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Protein]`_`f that in humans is encoded by the `*PIEZO2`* `F33f`_`[gene`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Gene]`_`f.`:cite-ref-entrez-5-0[`F5bf`_`[5`#cite-note-entrez-5]`_`f] It has a homotrimeric structure, with three blades curving into a nano-dome, with a diameter of 28 nanometers.`:cite-ref-6[`F5bf`_`[6`#cite-note-6]`_`f]

>>Contents

• `F0af`_`[Function`#function]`_`f

• `F0af`_`[Pathology`#pathology]`_`f

• `F0af`_`[See also`#see-also]`_`f

• `F0af`_`[References`#references]`_`f

• `F0af`_`[Further reading`#further-reading]`_`f

-─

>>Function

Piezos are large `F33f`_`[transmembrane proteins`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Transmembrane_protein]`_`f conserved among various species, all having between 24 and 36 predicted `F33f`_`[transmembrane domains`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Transmembrane_domain]`_`f. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The PIEZO2 protein has a role in rapidly adapting mechanically activated (MA) currents in somatosensory neurons.`:cite-ref-7[`F5bf`_`[7`#cite-note-7]`_`f] Its structure is resolved via a mouse version in 2019, showing the predicted homotrimeric propeller.`:cite-ref-8[`F5bf`_`[8`#cite-note-8]`_`f]

PIEZO2 is typically found in cell types that respond to physical touch, such as `F33f`_`[Merkel cells`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Merkel_cell]`_`f,`:cite-ref-9[`F5bf`_`[9`#cite-note-9]`_`f] and is thought to regulate light touch response.`:cite-ref-10[`F5bf`_`[10`#cite-note-10]`_`f]

>>Pathology

• Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal `F33f`_`[Arthrogryposis`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Arthrogryposis]`_`f.`:cite-ref-11[`F5bf`_`[11`#cite-note-11]`_`f]

• Mice without PIEZO2 in their proprioceptive neurons show uncoordinated body movements, indicating that PIEZO2 plays a role in mammalian `F33f`_`[proprioception`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Proprioception]`_`f.`:cite-ref-12[`F5bf`_`[12`#cite-note-12]`_`f]

• PIEZO2 mutations link `F33f`_`[Gordon syndrome`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Gordon_syndrome]`_`f (distal arthrogryposis type 3), `F33f`_`[Marden-Walker syndrome`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Marden-Walker_syndrome]`_`f and `F33f`_`[Arthrogryposis`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Arthrogryposis]`_`f (Distal Arthrogryposis Type 5).`:cite-ref-13[`F5bf`_`[13`#cite-note-13]`_`f]

>>See also

• `F33f`_`[PIEZO1`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PIEZO1]`_`f

>>References

`:cite-note-refgrch38ensembl-1`!1.`! GRCh38: Ensembl release 89: ENSG00000154864 – `F33f`_`[Ensembl`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Ensembl_genome_database_project]`_`f, May 2017

`:cite-note-refgrcm38ensembl-2`!2.`! GRCm38: Ensembl release 89: ENSMUSG00000041482 – `F33f`_`[Ensembl`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Ensembl_genome_database_project]`_`f, May 2017

`:cite-note-3`!3.`! "Human PubMed Reference:". `*National Center for Biotechnology Information, U.S. National Library of Medicine`*.

`:cite-note-4`!4.`! "Mouse PubMed Reference:". `*National Center for Biotechnology Information, U.S. National Library of Medicine`*.

`:cite-note-entrez-5`!5.`! `F0af`_`[↑`#cite-ref-entrez-5-0]`_`f "Entrez Gene: Piezo-type mechanosensitive ion channel component 2". Retrieved 2013-08-06.

`:cite-note-6`!6.`! `F0af`_`[↑`#cite-ref-6]`_`f `:citerefwangzhouzhangliu2019`aWang L, Zhou H, Zhang M, Liu W, Deng T, Zhao Q, et al. (September 2019). "Structure and mechanogating of the mammalian tactile channel PIEZO2". `*Nature`*. `!573`! (7773): 225–229. `F33f`_`[Bibcode`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Bibcode_(identifier)]`_`f:2019Natur.573..225W. `F33f`_`[doi`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Doi_(identifier)]`_`f:10.1038/s41586-019-1505-8. `F33f`_`[PMID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMID_(identifier)]`_`f 31435011. `F33f`_`[S2CID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=S2CID_(identifier)]`_`f 201116189.

`:cite-note-7`!7.`! `F0af`_`[↑`#cite-ref-7]`_`f `:citerefcostemathurschmidtearley2010`aCoste B, Mathur J, Schmidt M, Earley TJ, Ranade S, Petrus MJ, et al. (October 2010). "Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels". `*Science`*. `!330`! (6000): 55–60. `F33f`_`[Bibcode`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Bibcode_(identifier)]`_`f:2010Sci...330...55C. `F33f`_`[doi`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Doi_(identifier)]`_`f:10.1126/science.1193270. `F33f`_`[PMC`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMC_(identifier)]`_`f 3062430. `F33f`_`[PMID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMID_(identifier)]`_`f 20813920.

`:cite-note-8`!8.`! `F0af`_`[↑`#cite-ref-8]`_`f `:citerefwangzhouzhangliu2019`aWang L, Zhou H, Zhang M, Liu W, Deng T, Zhao Q, et al. (September 2019). "Structure and mechanogating of the mammalian tactile channel PIEZO2". `*Nature`*. `!573`! (7773): 225–229. `F33f`_`[Bibcode`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Bibcode_(identifier)]`_`f:2019Natur.573..225W. `F33f`_`[doi`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Doi_(identifier)]`_`f:10.1038/s41586-019-1505-8. `F33f`_`[PMID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMID_(identifier)]`_`f 31435011. `F33f`_`[S2CID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=S2CID_(identifier)]`_`f 201116189.

`:cite-note-9`!9.`! `F0af`_`[↑`#cite-ref-9]`_`f `:citerefwulewisgrandl2017`aWu J, Lewis AH, Grandl J (January 2017). "Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels". `*Trends in Biochemical Sciences`*. `!42`! (1): 57–71. `F33f`_`[doi`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Doi_(identifier)]`_`f:10.1016/j.tibs.2016.09.004. `F33f`_`[PMC`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMC_(identifier)]`_`f 5407468. `F33f`_`[PMID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMID_(identifier)]`_`f 27743844.

`:cite-note-10`!10.`! `F0af`_`[↑`#cite-ref-10]`_`f `:citereffaucherrenargeotmangonijopling2013`aFaucherre A, Nargeot J, Mangoni ME, Jopling C (October 2013). "piezo2b regulates vertebrate light touch response". `*The Journal of Neuroscience`*. `!33`! (43): 17089–94. `F33f`_`[doi`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Doi_(identifier)]`_`f:10.1523/jneurosci.0522-13.2013. `F33f`_`[PMC`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMC_(identifier)]`_`f 6618434. `F33f`_`[PMID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMID_(identifier)]`_`f 24155313.

`:cite-note-11`!11.`! `F0af`_`[↑`#cite-ref-11]`_`f `:citerefcostehougemurraystitziel2013`aCoste B, Houge G, Murray MF, Stitziel N, Bandell M, Giovanni MA, et al. (March 2013). "Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis". `*Proceedings of the National Academy of Sciences of the United States of America`*. `!110`! (12): 4667–72. `F33f`_`[Bibcode`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Bibcode_(identifier)]`_`f:2013PNAS..110.4667C. `F33f`_`[doi`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Doi_(identifier)]`_`f:10.1073/pnas.1221400110. `F33f`_`[PMC`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMC_(identifier)]`_`f 3607045. `F33f`_`[PMID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMID_(identifier)]`_`f 23487782.

`:cite-note-12`!12.`! `F0af`_`[↑`#cite-ref-12]`_`f `:citerefwoolukacsde-nooijzaytseva2015`aWoo SH, Lukacs V, de Nooij JC, Zaytseva D, Criddle CR, Francisco A, et al. (December 2015). "Piezo2 is the principal mechanotransduction channel for proprioception". `*Nature Neuroscience`*. `!18`! (12): 1756–62. `F33f`_`[doi`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Doi_(identifier)]`_`f:10.1038/nn.4162. `F33f`_`[PMC`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMC_(identifier)]`_`f 4661126. `F33f`_`[PMID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMID_(identifier)]`_`f 26551544.

`:cite-note-13`!13.`! `F0af`_`[↑`#cite-ref-13]`_`f `:citerefmcmillinbeckchongshively2014`aMcMillin MJ, Beck AE, Chong JX, Shively KM, Buckingham KJ, Gildersleeve HI, et al. (May 2014). "Mutations in PIEZO2 cause Gordon syndrome, Marden-Walker syndrome, and distal arthrogryposis type 5". `*American Journal of Human Genetics`*. `!94`! (5): 734–44. `F33f`_`[doi`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Doi_(identifier)]`_`f:10.1016/j.ajhg.2014.03.015. `F33f`_`[PMC`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMC_(identifier)]`_`f 4067551. `F33f`_`[PMID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMID_(identifier)]`_`f 24726473.

>>Further reading

• `:citerefuhertanseyhenigsbergwolfgang2013`aUher R, Tansey KE, Henigsberg N, Wolfgang M, Mors O, Hauser J, et al. (GENDEP Investigators; MARS Investigators; STAR*D Investigators) (February 2013). "Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies". `*The American Journal of Psychiatry`*. `!170`! (2): 207–17. `F33f`_`[doi`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Doi_(identifier)]`_`f:10.1176/appi.ajp.2012.12020237. `F33f`_`[PMC`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMC_(identifier)]`_`f 10416089. `F33f`_`[PMID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMID_(identifier)]`_`f 23377640.

• `:citerefahnwonleelee2012`aAhn MJ, Won HH, Lee J, Lee ST, Sun JM, Park YH, et al. (March 2012). "The 18p11.22 locus is associated with never smoker non-small cell lung cancer susceptibility in Korean populations". `*Human Genetics`*. `!131`! (3): 365–72. `F33f`_`[doi`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Doi_(identifier)]`_`f:10.1007/s00439-011-1080-z. `F33f`_`[PMID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMID_(identifier)]`_`f 21866343. `F33f`_`[S2CID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=S2CID_(identifier)]`_`f 16395362.

• `:citerefdel-aguilabeitelsheescooper-dehoffchapman2014`aDel-Aguila JL, Beitelshees AL, Cooper-Dehoff RM, Chapman AB, Gums JG, Bailey K, et al. (February 2014). "Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans". `*The Pharmacogenomics Journal`*. `!14`! (1): 35–40. `F33f`_`[doi`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Doi_(identifier)]`_`f:10.1038/tpj.2013.3. `F33f`_`[PMC`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMC_(identifier)]`_`f 3812324. `F33f`_`[PMID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMID_(identifier)]`_`f 23400010.

• `:citerefcostehougemurraystitziel2013`aCoste B, Houge G, Murray MF, Stitziel N, Bandell M, Giovanni MA, et al. (March 2013). "Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis". `*Proceedings of the National Academy of Sciences of the United States of America`*. `!110`! (12): 4667–72. `F33f`_`[Bibcode`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Bibcode_(identifier)]`_`f:2013PNAS..110.4667C. `F33f`_`[doi`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Doi_(identifier)]`_`f:10.1073/pnas.1221400110. `F33f`_`[PMC`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMC_(identifier)]`_`f 3607045. `F33f`_`[PMID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMID_(identifier)]`_`f 23487782.

• `:citerefwangshafferzengbegum2012`aWang X, Shaffer JR, Zeng Z, Begum F, Vieira AR, Noel J, et al. (December 2012). "Genome-wide association scan of dental caries in the permanent dentition". `*BMC Oral Health`*. `!12`!: 57. `F33f`_`[doi`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Doi_(identifier)]`_`f:10.1186/1472-6831-12-57. `F33f`_`[PMC`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMC_(identifier)]`_`f 3574042. `F33f`_`[PMID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMID_(identifier)]`_`f 23259602.

• `:citerefxiaoxu2010`aXiao R, Xu XZ (November 2010). "Mechanosensitive channels: in touch with Piezo". `*Current Biology`*. `!20`! (21): R936-8. `F33f`_`[Bibcode`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Bibcode_(identifier)]`_`f:2010CBio...20.R936X. `F33f`_`[doi`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Doi_(identifier)]`_`f:10.1016/j.cub.2010.09.053. `F33f`_`[PMC`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMC_(identifier)]`_`f 3018681. `F33f`_`[PMID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMID_(identifier)]`_`f 21056836.

• `:citerefcoste2011`aCoste B (January 2011). "[Feeling the pressure? Identification of two proteins activated by mechanical forces]". `*Médecine/Sciences`*. `!27`! (1): 17–9. `F33f`_`[doi`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Doi_(identifier)]`_`f:10.1051/medsci/201127117. `F33f`_`[PMID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMID_(identifier)]`_`f 21299953.

• `:citerefdubinschmidtmathurpetrus2012`aDubin AE, Schmidt M, Mathur J, Petrus MJ, Xiao B, Coste B, et al. (September 2012). "Inflammatory signals enhance piezo2-mediated mechanosensitive currents". `*Cell Reports`*. `!2`! (3): 511–7. `F33f`_`[doi`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Doi_(identifier)]`_`f:10.1016/j.celrep.2012.07.014. `F33f`_`[PMC`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMC_(identifier)]`_`f 3462303. `F33f`_`[PMID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMID_(identifier)]`_`f 22921401.

• `:citerefluykxbakkerlentjesneeleman2014`aLuykx JJ, Bakker SC, Lentjes E, Neeleman M, Strengman E, Mentink L, et al. (February 2014). "Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid". `*Molecular Psychiatry`*. `!19`! (2): 228–34. `F33f`_`[doi`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Doi_(identifier)]`_`f:10.1038/mp.2012.183. `F33f`_`[PMID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=PMID_(identifier)]`_`f 23319000. `F33f`_`[S2CID`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=S2CID_(identifier)]`_`f 8713026.

`*This article incorporates text from the `F33f`_`[United States National Library of Medicine`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=United_States_National_Library_of_Medicine]`_`f, which is in the `F33f`_`[public domain`:/page/wikibook/entry.mu`zim=wikipedia_en_all_nopic_2025-08.zim|entry_path=Public_domain]`_`f.`*

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